Type 3 innate lymphoid cells maintain intestinal epithelial stem cells after tissue damage

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Type 3 innate lymphoid cells maintain intestinal epithelial stem cells after tissue damage

Disruption of the intestinal epithelial barrier allows bacterial translocation and predisposes to destructive inflammation. To ensure proper barrier composition, crypt-residing stem cells continuously proliferate and replenish all intestinal epithelial cells within days. As a consequence of this high mitotic activity, mucosal surfaces are frequently targeted by anticancer therapies, leading to ...

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ژورنال

عنوان ژورنال: The Journal of Cell Biology

سال: 2015

ISSN: 0021-9525,1540-8140

DOI: 10.1083/jcb.2107oia193